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Tuesday, August 25, 2020

Hierarchies in resting-state brain activity


Abstract of the linked article:
The human cortex is characterized by local morphological features such as cortical thickness, myelin content, and gene expression that change along the posterior-anterior axis. We investigated if some of these structural gradients are associated with a similar gradient in a prominent feature of brain activity - namely the frequency of oscillations. In resting-state MEG recordings from healthy participants (N=187) using mixed effect models, we found that the dominant peak frequency in a brain area decreases significantly along the posterior-anterior axis following the global hierarchy from early sensory to higher-order areas. This spatial gradient of peak frequency was significantly anticorrelated with that of cortical thickness, representing a proxy of the cortical hierarchical level. This result indicates that the dominant frequency changes systematically and globally along the spatial and hierarchical gradients and establishes a new structure-function relationship pertaining to brain oscillations as a core organization that may underlie hierarchical specialization in the brain.

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