Thursday, November 28, 2024

Depression and Creativity

I’m working on an article about depression and decided to ask about the connection between depression and creativity. Claude makes a few general remarks and asks for my thoughts. So I mention some remarks that my teacher, David Hays, had made years ago, mentioning that he was a computational linguist. After some general remarks, Claude asks:

... did Hays develop this idea through his work in computational linguistics? It seems like there might be interesting parallels between how computer systems need to reorganize data structures and how human minds might need to reorganize mental frameworks.

Interesting, most interesting. Our ensuing interaction felt a bit like a real conversation. I was surprised and pleased. This felt a bit like, you know, real intelligence. But don't take any of it as ground truth. It's high class chit-chat.

I’ve appended its remarks below. I’m using my standard convention, setting my words in bold Courier and Claude’s reply in plain Courier.

Version: Claude 3.5 Sonnet

* * * * *

Is there evidence for a relationship between depression and creativity?

The relationship between depression and creativity is complex and has been studied extensively. The research shows several interesting patterns:

Historical observations have noted many renowned artists, writers, and musicians who experienced depression, like Virginia Woolf, Vincent van Gogh, and Sylvia Plath. However, we should be careful not to romanticize mental illness or assume correlation equals causation.

Scientific studies have found some evidence for links between depression and certain aspects of creativity:

Some research suggests that people with mood disorders may experience enhanced divergent thinking during certain phases, allowing them to generate more unique associations and ideas. The changes in emotional processing and perspective that can come with depression might contribute to seeing things in new ways or having deeper emotional insights.

However, severe depression typically impairs cognitive function and motivation, which can significantly reduce creative output. Many artists report that while their experiences with depression may inform their work, the actual creative process usually happens during periods of better mental health.

A key factor seems to be that creative pursuits can serve as a coping mechanism and form of emotional expression for people experiencing depression. The relationship may also be bidirectional - creative personalities might be more prone to rumination and emotional sensitivity.

What are your thoughts on this relationship between mental health and creativity? Have you observed any patterns in your own creative process?

That’s tricky. A teacher of mine, the computational linguist David Hays, thought that depression might indicate a process of mental reorganization that precedes a period of creativity. It’s as though you get stuck on a line of thought and have to undergo something like mental hibernation. During that “hibernation” the mind reorganizes.

That's a fascinating perspective from David Hays. His idea of depression as a period of mental reorganization or "hibernation" adds an interesting cognitive dimension to the discussion. It aligns with some modern theories about the potential adaptive functions of depression, particularly the "analytical rumination hypothesis" proposed by evolutionary psychologists.

This hypothesis suggests that depression's characteristic features - social withdrawal, reduced activity, and intense focus on problems - might serve to create mental space for working through complex problems or restructuring one's understanding. The "stuck" feeling you mentioned could represent this deep processing phase.

The metaphor of hibernation is particularly apt because it suggests both:

1. A necessary withdrawal or dormancy period
2. An underlying productive process that sets the stage for future growth

I'm curious - did Hays develop this idea through his work in computational linguistics? It seems like there might be interesting parallels between how computer systems need to reorganize data structures and how human minds might need to reorganize mental frameworks. His background in computational thinking might have given him unique insights into cognitive restructuring processes.

I think Hays primarily developed the idea from observing his own creative process. But he might also have been thinking about computers. Your remark about reorganizing data structures is suggestive. I know one thing that programmers do is refactor their code. That’s a specific kind of reorganization so it is more coherently organized.

The parallel between mental reorganization and code refactoring is quite illuminating. In refactoring, you don't change what the code does (its external behavior), but you restructure its internal organization to make it clearer, more efficient, or more maintainable. This often involves recognizing patterns that weren't obvious in the original implementation and finding a better way to express them.

This maps interestingly onto Hays's idea about depression and creativity. Just as a programmer might hit a point where the code has become too unwieldy and needs refactoring, a person might reach a point where their current mental models or ways of thinking have become inadequate for handling their experiences or insights. The depressive period could be like the uncomfortable but necessary process of pulling apart the existing structure to create something more robust.

What's particularly interesting is that both processes often require a kind of stepping back. When refactoring code, you often need to stop adding new features temporarily and focus on understanding the deeper patterns. Similarly, depression often involves a withdrawal from normal activities, which could serve a similar purpose of creating space for this deeper reorganization.

Did Hays discuss what might trigger these periods of necessary reorganization? I'm wondering if there are particular types of cognitive challenges or experiences that tend to precipitate this process.

Or think of an evolutionary process, where the species hits an evolutionary dead end. So it’s got to dedifferentiate and try again. Arthur Koestler used a French phrase to talk about this: “reculer pour mieux sauter.”

That's a brilliant connection! “Reculer pour mieux sauter” - step back to better jump forward - captures this idea perfectly. The evolutionary parallel really illuminates both Hays's theory about depression and the whole concept of creative restructuring.

In evolution, when a species hits a dead end, it can't just make small incremental changes anymore - it needs a more fundamental reorganization. Some evolutionary biologists talk about "despecialization" where organisms lose specialized features before developing new ones. This is similar to how stem cells need to dedifferentiate (become less specialized) before they can develop into new cell types.

This maps beautifully onto both:

  1. The depression-creativity cycle Hays described, where the mind needs to "dedifferentiate" or break down existing patterns before building new ones
  2. The creative process more generally, where sometimes you have to abandon your current approach entirely and return to a more basic state before finding a new path forward

It also suggests why this process can feel so uncomfortable or even frightening - you're temporarily giving up established structures or competencies in hopes of developing better ones. Just like an organism in the midst of evolutionary transition would be temporarily less well-adapted.

The French phrase really captures the intentionality or purposefulness of this retreat - it's not just stepping back, but stepping back specifically to gather force for a better leap forward.

It also relates to current work in machine learning and neural networks where an evolutionary style of computing is involved.

Yes! This connection to machine learning is really insightful. In artificial neural networks, there are several phenomena that mirror this "step back to leap forward" pattern:

  1. In gradient descent optimization, sometimes the system needs to move "uphill" temporarily (accepting worse performance) to escape a local minimum and find a better global solution. This is why techniques like simulated annealing deliberately introduce random noise or "temperature" to help the system explore more widely.
  2. In training neural networks, processes like "dropout" temporarily deactivate some neurons during training. This forced dedifferentiation helps prevent overfitting and leads to more robust learning - similar to how depression might force a "dropping out" of established mental patterns.
  3. In evolutionary algorithms and genetic programming, the concept of "reversion" or returning to less specialized states is built into operations like mutation and crossover. The system sometimes needs to break down existing solutions to explore new evolutionary pathways.

It's fascinating how these computational processes mirror biological evolution, creative thinking, and potentially the depression-creativity cycle Hays described. All seem to involve periods where existing structures or patterns need to be destabilized or broken down to enable new forms of organization to emerge.

Does this computational perspective add anything to your understanding of Hays's original insights about depression and creativity?

Yes, it does.

This feels like quite a profound convergence - we have parallel patterns across biological evolution, mental processes, and machine learning, all suggesting that progress sometimes requires a kind of productive regression or dedifferentiation. These aren't just metaphorical similarities but seem to point to a deeper principle about how complex systems develop and adapt.

The computational angle particularly strengthens Hays's insight by showing how this pattern emerges even in artificial systems designed purely for problem-solving. It suggests this isn't just a quirk of human psychology but potentially a fundamental principle of learning and adaptation in complex systems.

It makes me wonder what other domains might show this same pattern of "reculer pour mieux sauter." Are there examples in social systems, organizational change, or other areas where progress requires this kind of strategic regression?

“Strategic regression” – I love it.

What a great phrase to crystallize this idea! It really captures both the intentionality and the paradox - that sometimes moving backward is actually the most productive way forward. It helps remove the stigma from these apparent "regression" periods by highlighting their strategic value.

I imagine this concept could be really valuable in fields like education, therapy, or organizational development. It suggests that periods of apparent setback or loss of function might actually be necessary phases in development rather than just failures to progress.

This whole thread from Hays's original insight about depression through evolution, computing, and now to this broader principle of strategic regression feels like it's outlining something fundamental about how complex systems develop. Would you say this pattern of insight development itself might be an example of the principle - where we had to step back from the specific case of depression to see the broader pattern?

16 comments:

  1. Bill: "Yes, it does.
    LLM: "This feels like quite a profound convergence - we have parallel patterns across biological evolution, mental processes, and machine learning,..."

    Bill, ymmv re Friston and FEP.
    Friston: "- "90% of the neural net is not useful. There has to be a move away from big data to sparse data that is very well selected," Friston said, including the ability to forget data that is not relevant." [2]

    "Friston's free energy principle: new life for psychoanalysis?
    Published online by Cambridge University Press:  18 February 2021
    Jeremy Holmes
    ...
    "Free energy and psychopathology
    "The FEP has clear implications for those who work in mental ill health, and especially who favour psychological methods of treatment. Consider depression, typically triggered by loss, trauma or multiple setbacks. Adversity is widespread – poverty, inequality, racism – but not all succumb. To understand resilience, we need an illness model that encompasses not just events, but individuals’ responses to them. 
    ...
    "Such insecurely attached children are primed in later life for depression in response to loss or trauma or, in extreme cases, to developing post-traumatic stress disorder. The ingredients of free energy minimisation needed to maintain psychological equilibrium are for them problematic. Active inference is compromised. They tend to be passive rather than active. They stick with limited and simplistic and inflexible ‘top-down’ models such as ‘It's no use trying to make things better, it never works’ or ‘Feelings are dangerous, best to keep them buried’. They find it hard to trust people and so can't ‘borrow’ an intimate other's brain with which to process feelings and build up alternative ways of viewing the world.
    ...
    "MBT is both practically and conceptually consistent with the FEM. It encourages patients (a) ..."
    ...
    https://www.cambridge.org/core/journals/bjpsych-bulletin/article/fristons-free-energy-principle-new-life-for-psychoanalysis/384CC0D22585E17C2C9B2DA3757EE22D

    And, we've recently realised our amygdala may form a cleft over time due to affects of trauma and continual symptom, surprise signalling, making several spikes, delaying / interfering with 'correct' action signalling. Hard to de-cleft after forming. A bit newish I think, like FEP. But hey, it's Karl Friston!

    Where is Karl?
    Mar 13, 2024
    [2] "...and Verses' founders say today's most advanced large language models, like OpenAI's GPT-4, can't deliver it.
    -"There's no evidence of an ability to act outside its training data," CEO Gabriel René told Axios.

    "The big picture: Verses is working instead on what it calls distributed intelligence, using biology as its starting point, in the belief that AGI is only possible with a system that can self-organize and retrain in real time — as biological organisms do.

    "Verses chief scientist Karl Friston is betting this requires higher degrees of autonomy and computing efficiency than the current school of large model development allows.
    - Building on 30 scientific papers from its researchers, the company has developed Genius, an operating system for "continually learning autonomous agents" operating at the edge of our connected devices.
    - NASA's Jet Propulsion Laboratory and Volvo are among the beta users of Genius.

    "Minimizing complexity" is his "fundamental drive," Friston says. Instead of building ever-bigger AI models, Verses aims to deliver "99% smaller models" without sacrificing quality.
    - "90% of the neural net is not useful. There has to be a move away from big data to sparse data that is very well selected," Friston said, including the ability to forget data that is not relevant."
    ...
    https://www.axios.com/2024/03/13/verses-ai-artificial-general-intelligence-chatgpt

    ReplyDelete
    Replies
    1. Thanks for bringing Friston's work into the conversation.

      Delete
  2. And re...
    "Friston said, including the ability to forget data that is not relevant."

    "2:4 Sparse Llama: Smaller Models for Efficient GPU Inference
    ...
    "Neural Magic is doubling down on this challenge with sparse LLMs—reducing the model size by removing unneeded connections while retaining accuracy."
    ...
    https://neuralmagic.com/blog/24-sparse-llama-smaller-models-for-efficient-gpu-inference/

    How would the future be if humanity voted for ai's to forget???
    An interesting Q. The first thing which came to mind was showing my priors. Some of which I, and my -one day private secure local- ai definitely needs to forget.

    ReplyDelete
  3. Just read your 3QD article. My 3rd comment. 3 part 1.

    Bill, thanks for sharing. We need articles - and vulnerability. The graph reminded me of bipolar dissorder, not

    Your dalliance with Claude LLM sees you prompting - and prompting. And after your 2nd prompt, imho, you are providing a path similar to; "... the horse [LLM] gave the right answer only when the questioner knew what the answer was and the horse could see the questioner." The "Clever Hans Effect".
    "In honour of Pfungst's study, this type of artifact in research methodology has since been referred to as the Clever Hans effect and has continued to be important to the observer-expectancy effect and later studies in animal cognition."
    ...
    "The commission passed off the evaluation to Oskar Pfungst, who tested the basis for these claimed abilities by:
    - Isolating horse and questioner from spectators, so no cues could come from them
    - Using questioners other than the horse's master
    - By means of blinders, varying whether the horse could see the questioner
    - Varying whether the questioner knew the answer to the question in advance."
    https://en.wikipedia.org/wiki/Clever_Hans

    Pfungst's test constraints, imho, may provide you with a methodology;
    1) test both you and Claude LLM
    2) results of 1 then provides for a test against Claude, other LLMs, ... (this may also provide a "LLM creativity and accuracy score" - is hallucination crearive in an LLM?, and prompt LLM providers to justify themselves! Depression results e/affect humans), and
    3) results from 1 & 2 form the basis for asking / integrating metadata both lived experience and experts with treatment effectiveness ongoing model proof of veracity, and to weight models as per RLHF to assist Friston, me, and Christopher G Davey et al below, who writes;
    "The need to learn more about depression and how to treat it is pressing. Depression causes more disability than any other mental disorder and is one of the main causes of disability across the community. Despite this – and perhaps because of it – it remains a contested diagnosis."

    I hope you email Christopher G Davey. And Friston. Go on Bill. I just like Friston having read about his legendary open question sessions at UCL. I wish I had attended....
    "On a typical Monday, Karl Friston arrives on Queen Square at 12:25 pm and smokes a cigarette in the garden by the statue of Queen Charlotte. A slightly bent, solitary figure with thick gray hair, Friston is the scientific director of University College London’s storied Functional Imaging Laboratory, known to everyone who works there as the FIL. After finishing his cigarette, Friston walks to the western side of the square, enters a brick and limestone building, and heads to a seminar room on the fourth floor, where anywhere from two to two dozen people might be facing a blank white wall waiting for him. Friston likes to arrive five minutes late, so everyone else is already there.

    "His greeting to the group is liable to be his first substantial utterance of the day, as Friston prefers not to speak with other human beings before noon. "...
    https://www.wired.com/story/karl-friston-free-energy-principle-artificial-intelligence/
    ...

    ReplyDelete
    Replies
    1. 3.2..

      I really like Christopher G Davey et al use of top down and bottom up models, and trying to close the clinical gaps. Bravo.

      December 9, 2023
      "Understanding and explaining depression: From Karl Jaspers to Karl Friston"
      Christopher G Davey et al
      ...
      "Making sense of how prediction errors are processed requires introducing another component of predictive processing: the concept of precision. Precision refers to how reliable a prediction error is believed to be (it is the inverse of its variance). Our weighting of prediction errors – the degree to which we allow prediction errors to update the generative models – is influenced by our estimation of their precision and by how much confidence we have in our predictive models."...
      ...
      Symptoms of depression as precision-weighted prediction error
      ...
      "The altered confidence in the generative models is expressed in changes at the synapse, where the neuromodulators that weight precision exert their influence. It is for this that Friston (2023) describes mental illnesses such as depression as synaptopathies. But to describe depression in this way is not to side with the influence of biology against social effects. The active inference framework provides a way of linking social determinants to brain function. Poverty and marginalisation create instability, which are reflected in generative models that encode the uncertainty at the synaptic level by changes in the precision weighting of prediction errors (Badcock et al., 2017). Social determinants are sometimes discussed as causing depression as if they travel through an aether or miasma: but they must ultimately affect brain function to cause depression, and the active inference model outlines a mechanistic framework by which this might occur.

      "The framework helps to explain individual differences in the types of symptoms that are experienced."...
      ...
      https://doi.org/10.1177/00048674231219178

      You may also like:
      Friston K.
      "Maps and territories, smoke, and mirrors."
      Behav Brain Sci. 2022 Sep 29;45:e195.
      Abstract
      "It is a pleasure to comment on Bruineberg et al. - who raise some interesting questions of a philosophical and technical nature. I will try to answer three questions posed by the authors. Are Pearl and Friston blankets different things? Are Markov blankets used in an ontological sense? Is there a privileged Markov blanket?"
      doi: 10.1017/S0140525X22000073. PMID: 36172761.

      Finally here is Friston et al on;
      "Cultivating creativity: predictive brains and the enlightened room problem"
      Axel Constant, Karl John Friston, Andy Clark 
      ...
      "In what follows, we offer a proof of principle for this kind of environmentally led cognitive expansion." ... "This article is part of the theme issue ‘Art, aesthetics and predictive processing: theoretical and empirical perspectives’."
      DOI: 10.1098/rstb.2022.0415
      ISSN: 0962-8436

      Bet now your depression low and creativity high. Best.

      Delete
  4. Ah, you've been working. Among other things you've raised the possibility that 1) I've been investigating a case of bipolar disorder without knowing it. Well, if it turns out that bipolar disorder is the appropriate name, that's OK with me. Then the issue becomes whether or not I've added anything, not necessarily much, but anything at all, to our understanding of bipolar disorder. Since I’m not familiar with that literature I’m in no position to answer that question.

    I should add that it does seem to me that “depression” is a label that gets applied to a relatively wide variety of behavior. There’s no reason to think that they all have the same causal structure.

    I like to think about traffic jams. What causes traffic jams? When the number cars trying to travel a particular stretch of road exceeds the road’s capacity, we have a traffic jam. But road capacity can be constricted in various ways. Maybe a large tree has fallen onto the road. Maybe there’s been an accident and, while the vehicles involved are not in the roadway, people driving by are curious and slow down to look. Or maybe the weekend’s over and everyone is driving back to the city (from visiting friends, or staying at their cottage) at the same time. Different causes, same effect.

    2) LLMs & “hallucination”: Once I started playing around with ChatGPT back in December 2022 I quickly discovered that it confabulates. I thought about it a bit and decided that the problem was inherent in the architecture. We might be able to mitigate it, but we can’t eliminate it.

    I also came to the belief that, in effect, “hallucination” is the inherent condition of the nervous system. In investigations of sensory deprivation going back into the mid 20th century we’ve found out that when people are deprived of sensory input, they hallucinate (for real, no scare quotes). We need the “pressure” of sensory input to keep the system stable.

    3) Clever Hans: Well, yes, Claude does aim to please and in this particular interaction I was actively looking for something. Claude was happy to oblige.

    4) “Predictive process” has been my working hypothesis for decades, though not under that label. Back in 1973 Wm Powers published “Behavior: The Control of Perception,” which I read a couple of years later. He’s coming from classical control theory (Wiener et al.) & argues that we’re always expecting things and process inputs against those expectations.

    5) Thanks for the citations in you last comment.

    ReplyDelete
  5. Oh, on "hallucinations," the only way to eliminate them is to figure out what's actually going on. Sometimes that's as easy as looking out the window. Other times it requires a bunch of investigators working hard over a period of decades. Reality doesn't make things easy for us.

    ReplyDelete
  6. Finally, "Bet now your depression low and creativity high" – yes. I started pulling out in the middle of last month. I'm working on a post where I discuss my DAILY posting habits in Oct & Nov and also about getting up in the middle of the night in order to work. I've got a number of posts labeled "Segmented_sleep". You might want to look through them.

    ReplyDelete
  7. I’ve blitzed through the Friston portion of the Davey and it makes sense to me, but I need to think about it some more and poke around on the neurochemical angle. Note, though, that when I talk about reorganization, I’m certainly implicating those synapses even though I don’t mention that in what I’ve written.

    As for bipolar disorder, I asked Claude for some basic stuff. It told me about Bipolar I and Bipolar II. Bipolar II seemed more plausible, so I asked for more. Some of what it told me:

    “Hypomanic episodes in Bipolar II Disorder typically last between 2 to 7 days, with a minimum duration requirement of 4 consecutive days for clinical diagnosis. The episodes can sometimes extend up to 2 weeks, though this is less common. By definition, these episodes must represent a clear change from the individual's normal functioning but cannot be severe enough to cause marked impairment or require hospitalization, as this would indicate full mania.”

    My up phases last for months, not days or weeks. And most of that time certainly involves my normal functioning. However, there are periods when I often get up during the night to work and have lots of ideas, more than I have time to track down (immediately). I’m in such a period now and will be writing a post about it.

    And then:

    “The duration and frequency of depressive episodes in Bipolar II Disorder can vary significantly among individuals. According to clinical guidelines, depressive episodes typically last between 6 and 8 months, though they can range from as brief as 2 weeks to as long as several years if left untreated.”

    “Regarding frequency, research indicates that individuals with Bipolar II Disorder experience an average of four episodes per year, though this can range from one to twelve episodes annually. Some individuals may experience more rapid cycling, defined as four or more episodes within a single year. This pattern occurs in approximately 20% of people with Bipolar II.”

    My down phases seem to be about 3 to 4 months and I get one of them per year. Until two years ago they happened in the winter months. The fact that that stopped is what got me thinking about this.

    Bipolar II doesn’t seem like a good fit.

    ReplyDelete
  8. Serenditpity at work.via Dipity.
    I was going to paraphrase Jaron Lanier re... software is crap and will always be... my priors causing my attention to ? minimise my free energy???
    And what pops out this time, due to your writings Bill (thanks) on depression and creativity....

    "4) That what Darwin described in biology, or something like it, is in fact also the singular, superior description of all creativity and culture. "

    May just be a footnote in history though. ymmv.
    I note that both Jaron Lanier and Luckey Palmer created VR headsets at opposite ends of the tech spectrum, and both went on to create weapons. In Jaron's case, seemingly using the tech to augment what DARPA may take up. In Luckey Palmers case, a pissed off smart techno rich kid;
    'Luckey left Facebook in March 2017, alleging he had been fired for his pro-Trump beliefs, which Facebook denies.[5][13] " Wikipedia
    ... disrupting the miltary industrial complex, one Thiel backed private rented destruction system at a time.

    Two techho creatives, entirely at opposing ends imo. One only should have been depressed and rewired his brain for good. The other plays music. Instead we get J. R. R. Tolkien's nightmare creations on steriods, turned into creative destrucrive weapons: "Anduril Industries is named for Andúril, the fictional sword of Aragorn from The Lord of the Rings.[8] Translated from the novels' constructed language Quenya, the name means Flame of the West.[9]" Wikipedia

    A creative spur to create weapons and invoke Jaron's warning... "Or bigger, since these ideas might end up essentially built into the software that runs our society and our lives. If that happens, the ideology of cybernetic totalist intellectuals will be amplified from novelty into a force that could cause suffering for millions of people."
    Depressing, and creative! Oh, humans.

    "ONE HALF A MANIFESTO
    By Jaron Lanier
    ...
    ""There is a real chance that evolutionary psychology, artificial intelligence, Moore's Law fetishizing, and the rest of the package, will catch on in a big way, as big as Freud or Marx did in their times. Or bigger, since these ideas might end up essentially built into the software that runs our society and our lives. If that happens, the ideology of cybernetic totalist intellectuals will be amplified from novelty into a force that could cause suffering for millions of people."
    ...
    "Here is a partial roster of the component beliefs of cybernetic totalism:
    ...
    4) That what Darwin described in biology, or something like it, is in fact also the singular, superior description of all creativity and culture. 
    ...
    "I do sometimes wonder if some of the students I work with who have gone on to dot com riches would be able to handle any financial frustration that lasted more than a few days without going into some sort of destructive depression or rage."
    ...
    "Belief #4: That what Darwin described in biology, or something like it, is in fact also the singular, superior description of all possible creativity and culture.

    "Cybernetic totalists are obsessed with Darwin, for he described the closest thing we have to an algorithm for creativity. Darwin answers what would otherwise be a big hole in the Dogma: How will cybernetic systems be smart and creative enough to invent a post-human world? In order to embrace an eschatology in which the computers become smart as they become fast, some kind of Deus ex Machina must be invoked, and it has a beard.
    ...
    "Is it not possible that there remains an as-yet unarticulated idea that explains aspects of achievement and creativity that Darwin does not?
    ...
    Freeman Dyson
    ..."Obviously, that's the direction you have to go if you want to combine robustness with creativity. All I can say is, why didn't I think of that?"
    ...
    https://www.edge.org/conversation/jaron_lanier-one-half-a-manifesto

    ReplyDelete
  9. Last one for a while. No need of reponse Bill I may be taking you off task..

    And don't neglect your gut...
    Lu Y, Yu X, Wang Z, Kong L, Jiang Z, Shang R, Zhong X, Lv S, Zhang G, Gao H, Yang N.
    "Microbiota-gut-brain axis: Natural antidepressants molecular mechanism."
    Phytomedicine. 2024 Nov;134:156012. doi: 10.1016/j.phymed.2024.156012

    I'll await your further musings after digestion.
    Cheers, Dipity.

    ReplyDelete
  10. The moniker you've taken for yourself reminds me of this song from the Ancient Days: https://www.youtube.com/watch?v=zDePvXpYhzA

    ReplyDelete
  11. Thanks for the links. I'll get around to it, eventually.

    ReplyDelete
  12. Last one as ai is a firehose.

    "New report: Taking AI Welfare Seriously
    Our new report argues that there is a realistic possibility of consciousness and/or robust agency—and thus moral significance—in near-future AI systems, and makes recommendations for AI companies. (Joint output with the NYU Center for Mind, Ethics, and Policy.)

    "Eleos AI is pleased to release a new report! 
    ...
    "Read the full report here. Read a short summary here.
    https://eleosai.org/post/taking-ai-welfare-seriously/

    ReplyDelete
  13. Not yet, but "yes," it's an issue.

    ReplyDelete
  14. Polirical melancholia?

    DEC. 2, 2024
    "God is dead and my enemies are in power"
    ...
    "Thinking about this today has brought me back for what feels like the 20th time to Wendy Brown’s “Resisting left melancholy” from 1999.
    https://www.jstor.org/stable/303736
    "This essay is a reading of Walter Benjamin and Stuart Hall through Freud. Brown starts with Stuart Hall’s diagnosis of the UK Left in the shadow of Thatcherism; he attributes its perpetual defeat and back-footedness to its own “failure to apprehend the the character of the age and to develop a political critique and a moral-political vision appropriate to this character” (Brown’s words). Bringing in Walter Benjamin, Brown continues:"...
    ...
    "She goes on to connect this to Freud’s notion of melancholia as unconscious object-loss — I am way out of my depth with Freud, so my apologies if this is a clumsy paraphrase. For Brown, the unconscious loss at the “hollow core” of the laundry list of other left-wing defeats from which this left melancholy radiates like throbbing pain from a strained back muscle (heyo) is the loss of the “promise that left analysis and left commitment would supply its adherents a clear and certain path toward the good, the right, and the true.” I mean, damn. I feel like we can see this all over the hopeless, joyless Sturm und Drang of The Discourse(TM) as it relates to public health and science politics in the COVID era.
    ...
    https://buttondown.com/abbycartus/archive/god-is-dead-and-my-enemies-are-in-power/

    Dipity Sync.

    ReplyDelete