I assume there's an erotic reference involved. Whether or not it has much of anything to do with what might be a hole in the wall at the 'crotch' of the heart, I don't know. I didn't look, though I've been on the other side of that wall.
But what's that white lumpy thing draped over the heart? I could be a cloud; that was my initial reaction. But now I wonder. Maybe it's a (crude) image of the human brain, and the "y" in glory marks the Sylvan fissure. That puts the "Hole" on the temporal lobe and "Glory" on the lateral frontal lobe.
ADDENDUM: I decided to check. This is what you see when you look through the whole in the wall: